The Bioinformatics Application in Detecting Germline and Somatic Variants towards Breast Cancer using Next Generation Sequencing

Breast cancer is the type of with most and highest cases causing mortality in Indonesia, so an effective treatment required to reduce incidence rate due breasts. Most breast patients are diagnosed at advanced stage used limited risk death becomes higher. Along development human genome sequencing technology, genetic examination considered as that can be for early prevention management personally. Based on target variants detected, divided into two, namely germline somatic variants. Germline variant intended predict which preventive measure, while diagnosis therapy. NGS technology able detect both types a number genes associated several samples effectively quickly. However, data generated from very large complex, role bioinformatics analyzing interpreting data. By utilizing pipelines tools, analysis carried out accurately results examinations step treat cancer.